EC 1.14.14.23 CYP7A1 2 reactions
Rate-limiting for bile acid synthesis; up-regulated by bile acid sequestrants
Enzymes & cofactors
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EC 1.14.15.18 CYP27B1 1 reactions
Vitamin D-dependent rickets type 1; stimulated by PTH, suppressed by FGF-23
EC 1.14.15.16 CYP24A1 1 reactions
EC 1.13.11.27 HPD 1 reactions
EC 1.13.11.34 ALOX5 1 reactions
Zileuton target; leads to leukotrienes
EC 7.1.1.9 MT-CO1-3 1 reactions
Inhibited by cyanide, carbon monoxide, azide, H2S
1 reactions
EC 1.3.3.3 CPOX 1 reactions
EC 1.14.99.1 PTGS1/PTGS2 1 reactions
Irreversibly acetylated by aspirin; NSAID and coxib target
1 reactions
EC 1.14.14.1 CYP genes 1 reactions
CYP3A4 handles ~50% of drugs; major site of drug-drug interactions
EC 1.14.19.17 DEGS1 1 reactions
EC 7.1.2.2 ATP5 genes 1 reactions
Inhibited by oligomycin; bypassed by uncouplers (DNP, UCP1)
EC 4.1.1.90 GGCX 1 reactions
Carboxylates factors II, VII, IX, X, protein C, S, Z
EC 1.14.14.18 HMOX1 1 reactions
Produces biliverdin, CO and Fe2+; rate-limiting for heme catabolism
EC 1.13.11.5 HGD 1 reactions
Alkaptonuria: dark urine on standing, ochronosis, arthritis
1 reactions
EC 1.4.3.4 MAOA/MAOB 1 reactions
MAOI + tyramine: hypertensive crisis
EC 1.14.16.1 PAH 1 reactions
Phenylketonuria: musty odour, intellectual disability, hypopigmentation; BH4 defects cause malignant PKU
EC 1.3.3.4 PPOX 1 reactions