unreviewed

Complex IV (cytochrome c oxidase)

1 reactions · 1 pathways

Cofactors used

Cu · Copper Fe2+ · Iron H2O Heme/cytochrome · Iron O2

Clinical / pharmacological. Inhibited by cyanide, carbon monoxide, azide, H2S

What it does, reaction by reaction

1 reactions

Electron Transport Chain (Complexes I–IV) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane

step 4 Irreversible/directional

2 cytochrome c(Fe2+) + 1/2 O2 + 2 H+matrix → 2 cytochrome c(Fe3+) + H2O

Converts Cytochrome c(Fe2+) O2 H+ (matrix) into Cytochrome c(Fe3+) H2O

› Notes

Required cofactors: CuA center, hemes a and a3, CuB, cytochrome c, O2, and matrix protons. Per pair of electrons (one NADH equivalent), Complex IV pumps 2 H+ from matrix to intermembrane space and also consumes 2 matrix H+ chemically to form water; for four electrons/O2 it pumps 4 H+ and consumes 4 matrix H+.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Load 10 most recent

Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.

Europe PMC · ten most recent, newest first