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MS
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F0F1-ATP synthase (coupling stoichiometry)

1 reactions · 1 pathways

Clinical / pharmacological. Inhibited by oligomycin; bypassed by uncouplers (DNP, UCP1)

What it does, reaction by reaction

1 reactions

Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane

step 6 Irreversible/directional

Coupling stoichiometry and P/O outcome: reducing equivalents + ADP + Pi + O2 → ATP + H2O

Converts Reducing equivalents ADP Pi O2 into ATP H2O

Notes

Thus, about 10 H+ pumped per NADH supports approximately 2.5 ATP, and about 6 H+ per FADH2 supports approximately 1.5 ATP. This P/O relationship is an average bioenergetic estimate, not a fixed invariant, because proton leak, substrate transport, tissue state, and shuttle choice affect observed yields.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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