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rate-limiting unreviewed

Cytochrome P450 monooxygenases (CYP)

1 reactions · 1 pathways

Cofactors used

CYP reductase heme NADPH ยท B3 (Niacin) O2

Clinical / pharmacological. CYP3A4 handles ~50% of drugs; major site of drug-drug interactions

What it does, reaction by reaction

1 reactions

Phase I - Functionalization Xenobiotic & Drug Metabolism · Smooth ER (microsomes), mitochondria

step 1 Irreversible/directional rate-limiting

Drug + O2 + NADPH -> hydroxylated/oxidized drug + H2O + NADP+

Converts O2 NADPH into Hydroxylated/oxidized drug H2O NADP+

› Notes

Smooth ER of hepatocytes. Introduces or exposes a polar group. CYP3A4 handles roughly half of all drugs.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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