Enzymes & cofactors

Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.

Enzymes Cofactor terms Vitamins & minerals

Cofactor / coenzyme

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Showing enzymes whose reactions use heme. Remove

Cholesterol 7-alpha-hydroxylase (CYP7A1) RL

EC 1.14.14.23 CYP7A1 2 reactions

Rate-limiting for bile acid synthesis; up-regulated by bile acid sequestrants

Cyclooxygenase (COX-1 / COX-2; PTGS1/2) RL

EC 1.14.99.1 PTGS1/PTGS2 1 reactions

Irreversibly acetylated by aspirin; NSAID and coxib target

Cytochrome P450 monooxygenases (CYP) RL

EC 1.14.14.1 CYP genes 1 reactions

CYP3A4 handles ~50% of drugs; major site of drug-drug interactions

Nitric oxide synthase (nNOS/eNOS/iNOS)

EC 1.14.13.39 NOS1-3 1 reactions

NO -> cGMP; nitrate and PDE5-inhibitor axis

Showing all 4 enzymes.