rate-limiting unreviewed

Cyclooxygenase (COX-1 / COX-2; PTGS1/2)

1 reactions · 1 pathways

Cofactors used

heme O2

Clinical / pharmacological. Irreversibly acetylated by aspirin; NSAID and coxib target

What it does, reaction by reaction

1 reactions

Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane

step 2 Irreversible rate-limiting

Arachidonic acid + 2 O2 -> PGG2 -> PGH2

Converts Arachidonic acid O2 into PGG2

› Notes

Bifunctional cyclooxygenase + peroxidase. Irreversibly acetylated by aspirin; reversibly inhibited by other NSAIDs; COX-2 selectively inhibited by coxibs.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

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