Nitric oxide synthase (nNOS/eNOS/iNOS)
Cofactors used
Clinical / pharmacological. NO -> cGMP; nitrate and PDE5-inhibitor axis
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Arginine + O2 + NADPH -> nitric oxide + L-citrulline
Converts Arginine O2 NADPH into Nitric oxide L-citrulline
› Notes
NO activates soluble guanylate cyclase -> cGMP -> smooth-muscle relaxation; the mechanism exploited by nitrates and by PDE5 inhibitors.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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