EC 1.5.1.3 DHFR 3 reactions
Target of methotrexate, trimethoprim, pyrimethamine
Enzymes & cofactors
Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.
Showing enzymes whose reactions use NADPH.
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EC 1.1.1.21 AKR1B1 2 reactions
Target of aldose reductase inhibitors; polyol accumulation in diabetes
EC 1.14.14.23 CYP7A1 2 reactions
Rate-limiting for bile acid synthesis; up-regulated by bile acid sequestrants
EC 1.3.1.2 DPYD 2 reactions
DPD deficiency: severe 5-fluorouracil toxicity
EC 1.14.15.18 CYP27B1 1 reactions
Vitamin D-dependent rickets type 1; stimulated by PTH, suppressed by FGF-23
EC 1.14.15.16 CYP24A1 1 reactions
EC 1.1.1.102 KDSR 1 reactions
EC 1.1.1.44 PGD 1 reactions
EC 2.3.1.85 FASN 1 reactions
EC 1.3.1.24 BLVRA 1 reactions
1 reactions
EC 1.14.14.1 CYP genes 1 reactions
CYP3A4 handles ~50% of drugs; major site of drug-drug interactions
EC 1.1.1.40 ME1 1 reactions
EC 2.3.1.85 FASN 1 reactions
EC 2.5.1.21 FDFT1 1 reactions
EC 1.1.1.49 G6PD 1 reactions
G6PD deficiency: oxidative haemolysis, Heinz bodies, bite cells, favism
EC 1.4.1.3 GLUD1 1 reactions
Activating mutations: hyperinsulinism-hyperammonaemia syndrome
EC 1.8.1.7 GSR 1 reactions
FAD/riboflavin-dependent; links GSH recycling to the pentose phosphate pathway
1 reactions
EC 1.14.14.18 HMOX1 1 reactions
Produces biliverdin, CO and Fe2+; rate-limiting for heme catabolism