rate-limiting unreviewed
ER-associated squalene synthase
1 reactions · 1 pathways
Cofactors used
What it does, reaction by reaction
1 reactions
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
step 11
Irreversible/directional
2 FPP + NADPH + H+ → squalene + 2 PPi + NADP+
Converts Farnesyl pyrophosphate (FPP) NADPH H+ into Squalene PPi NADP+
› Notes
ER-associated squalene synthase makes the C30 hydrocarbon through presqualene pyrophosphate. This is the first committed step toward sterol formation after FPP; NADPH is required.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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