EC 1.5.1.3 DHFR 3 reactions
Target of methotrexate, trimethoprim, pyrimethamine
Enzymes & cofactors
Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.
Showing enzymes whose reactions use NADP+.
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EC 1.1.1.21 AKR1B1 2 reactions
Target of aldose reductase inhibitors; polyol accumulation in diabetes
EC 1.3.1.2 DPYD 2 reactions
DPD deficiency: severe 5-fluorouracil toxicity
EC 1.1.1.44 PGD 1 reactions
EC 2.3.1.85 FASN 1 reactions
EC 1.3.1.24 BLVRA 1 reactions
EC 1.1.1.40 ME1 1 reactions
EC 2.3.1.85 FASN 1 reactions
EC 2.5.1.21 FDFT1 1 reactions
EC 1.1.1.49 G6PD 1 reactions
G6PD deficiency: oxidative haemolysis, Heinz bodies, bite cells, favism
EC 1.4.1.3 GLUD1 1 reactions
Activating mutations: hyperinsulinism-hyperammonaemia syndrome
EC 1.14.14.18 HMOX1 1 reactions
Produces biliverdin, CO and Fe2+; rate-limiting for heme catabolism
EC 1.1.1.34 HMGCR 1 reactions
Target of statins; SREBP-2 regulated
EC 1.5.1.5 MTHFD1 1 reactions
EC 1.5.1.20 MTHFR 1 reactions
MTHFR variants: hyperhomocysteinaemia
EC 1.14.14.17 SQLE 1 reactions
1 reactions
Showing all 17 enzymes.