Thioredoxin reductase (TXNRD)
Cofactors used
What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
Oxidized thioredoxin → reduced thioredoxin
Converts Oxidized thioredoxin into Reduced thioredoxin
› Notes
Thioredoxin reductase catalyzes oxidized thioredoxin + NADPH + H+ → reduced thioredoxin + NADP+. This FAD- and selenocysteine-containing flavoprotein restores the RNR electron donor after each catalytic cycle. The glutaredoxin alternative is sustained by glutathione reductase, which uses NADPH to regenerate reduced glutathione.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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