Cytosolic, NADP+-dependent malic enzyme
Cofactors used
What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Malate + NADP+ → pyruvate + CO2 + NADPH + H+
Converts Malate NADP+ into Pyruvate CO2 NADPH H+
› Notes
Cytosolic, NADP+-dependent malic enzyme produces NADPH and pyruvate. Pyruvate returns to mitochondria and can be carboxylated to oxaloacetate by pyruvate carboxylase (ATP and biotin required), completing the shuttle; the pentose-phosphate pathway is another major NADPH source.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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