unreviewed

Squalene monooxygenase (squalene epoxidase)

1 reactions · 1 pathways

Cofactors used

FAD · B2 (Riboflavin) H2O NADP+ · B3 (Niacin) NADPH · B3 (Niacin) O2

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 12 Irreversible/directional

Squalene + O2 + NADPH + H+ → (S)-2,3-oxidosqualene + NADP+ + H2O

Converts Squalene O2 NADPH H+ into (S)-2,3-Oxidosqualene NADP+ H2O

› Notes

Squalene monooxygenase (squalene epoxidase), an FAD-dependent ER monooxygenase, uses NADPH and oxygen to form the epoxide. This is an important secondary regulatory point.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Cholesterol Biosynthesis (Mevalonate Pathway)

Listed there as: Squalene monooxygenase

Accelerated by

Low cholesterol; increased substrate squalene

Inhibited by

Cholesterol-dependent degradation

Hormonal control

Responds predominantly to sterol-dependent proteostasis, with indirect insulin/feeding effects

Recent literature

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