rate-limiting unreviewed

Glucose-6-phosphate dehydrogenase (G6PD)

1 reactions · 1 pathways

Cofactors used

NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

Clinical / pharmacological. G6PD deficiency: oxidative haemolysis, Heinz bodies, bite cells, favism

What it does, reaction by reaction

1 reactions

Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism · Cytosol

step 1 Irreversible rate-limiting

Glucose-6-phosphate + NADP+ → 6-phosphoglucono-delta-lactone + NADPH + H+

Converts Glucose-6-phosphate NADP+ into 6-Phosphoglucono-delta-lactone NADPH H+

› Notes

Glucose-6-phosphate dehydrogenase (G6PD) uses NADP+ and is the first, rate-limiting, committed, and irreversible oxidative PPP reaction. It generates the first NADPH and is stimulated by a high NADP+/NADPH ratio.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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