Methylene-THF dehydrogenase (MTHFD1)
Cofactors used
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
5,10-Methylene-THF + NADP⁺ ⇌ 5,10-methenyl-THF + NADPH + H⁺
Converts 5,10-Methylene-THF NADP+ into 5,10-Methenyl-THF NADPH H+
› Notes
The dehydrogenase activity of cytosolic trifunctional MTHFD1 (or mitochondrial MTHFD2/MTHFD2L) interconverts these folate species. Cofactor preference is enzyme- and compartment-specific; MTHFD1 uses NADP⁺, whereas mitochondrial MTHFD2 commonly uses NAD⁺.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.
Europe PMC · ten most recent, newest first