unreviewed

Biliverdin reductase (BLVRA)

1 reactions · 1 pathways

Cofactors used

NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut

step 2 Irreversible/directional

Biliverdin IXα + NADPH + H⁺ → bilirubin IXα + NADP⁺

Converts Biliverdin IX-alpha NADPH H+ into Bilirubin IX-alpha NADP+

› Notes

Cytosolic biliverdin reductase reduces the central methine bridge to form unconjugated bilirubin. NADPH is required; bilirubin is hydrophobic and is released into plasma bound tightly but noncovalently to albumin.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Degradation (Bilirubin Pathway)

Listed there as: Biliverdin reductase

Accelerated by

Biliverdin and NADPH availability

Inhibited by

NADPH deficiency/product accumulation

Hormonal control

No major direct hormonal control

Recent literature

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