Methylenetetrahydrofolate reductase (MTHFR)
Cofactors used
Clinical / pharmacological. MTHFR variants: hyperhomocysteinaemia
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
5,10-Methylene-THF + NADPH + H⁺ → 5-methyl-THF + NADP⁺
Converts 5,10-Methylene-THF NADPH H+ into 5-Methyl-THF NADP+
› Notes
Methylenetetrahydrofolate reductase (MTHFR) uses FAD as a prosthetic group and NADPH-derived reducing power to generate 5-methyl-THF. This is an effectively irreversible, regulated branch-point reaction that commits one-carbon units to methionine regeneration rather than nucleotide synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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