rate-limiting unreviewed

1-alpha-hydroxylase (CYP27B1)

1 reactions · 1 pathways

Cofactors used

NADPH · B3 (Niacin) O2

Clinical / pharmacological. Vitamin D-dependent rickets type 1; stimulated by PTH, suppressed by FGF-23

What it does, reaction by reaction

1 reactions

Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria

step 3 Irreversible rate-limiting

25-Hydroxyvitamin D -> 1,25-dihydroxyvitamin D (calcitriol)

Converts 25-Hydroxyvitamin D (calcidiol) into 1,25-Dihydroxyvitamin D

› Notes

Rate-limiting and tightly regulated step, in the proximal renal tubule: up-regulated by PTH and hypophosphataemia, suppressed by FGF-23 and by calcitriol itself.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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