gamma-Glutamyl carboxylase (GGCX)
Cofactors used
Clinical / pharmacological. Carboxylates factors II, VII, IX, X, protein C, S, Z
What it does, reaction by reaction
Vitamin K Cycle Cofactor & Vitamin Metabolism · ER membrane
Glutamate residue + CO2 + O2 + vitamin K hydroquinone -> gamma-carboxyglutamate + vitamin K epoxide
Converts Glutamate residue CO2 O2 Vitamin K hydroquinone into gamma-carboxyglutamate Vitamin K epoxide
› Notes
Gla residues chelate Ca2+ and anchor factors II, VII, IX, X and proteins C, S and Z to phospholipid membranes; also osteocalcin and matrix Gla protein.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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