unreviewed

Protoporphyrinogen oxidase (PPOX)

1 reactions · 1 pathways

Cofactors used

FAD · B2 (Riboflavin) O2

What it does, reaction by reaction

1 reactions

Heme Biosynthesis (Porphyrin Pathway) Amino Acid & Nitrogen Metabolism · Mitochondrion + cytosol

step 7 Irreversible

Protoporphyrinogen IX + 3 O₂ → protoporphyrin IX + 3 H₂O₂ (net oxidation)

Converts Protoporphyrinogen IX O2 into Protoporphyrin IX H2O2

› Notes

Protoporphyrinogen oxidase (PPOX), a FAD-dependent enzyme associated with the inner mitochondrial membrane, oxidizes the reduced porphyrinogen to the conjugated porphyrin. Molecular oxygen is the terminal electron acceptor; this step is essentially irreversible.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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