Homogentisate 1,2-dioxygenase (HGD)
Cofactors used
Clinical / pharmacological. Alkaptonuria: dark urine on standing, ochronosis, arthritis
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Homogentisate + O₂ → maleylacetoacetate
Converts Homogentisate O2 into Maleylacetoacetate
› Notes
Homogentisate 1,2-dioxygenase opens the aromatic ring using Fe²⁺. Deficiency blocks this reaction and causes alkaptonuria.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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