Skip to content
MS
unreviewed

5-Lipoxygenase (ALOX5) + FLAP

1 reactions · 1 pathways

Cofactors used

Clinical / pharmacological. Zileuton target; leads to leukotrienes

What it does, reaction by reaction

1 reactions

Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane

step 4 Irreversible/directional

Arachidonic acid + O2 -> 5-HPETE -> LTA4

Converts Arachidonic acid O2 into 5-HPETE

Notes

Branch point of the leukotriene arm; zileuton inhibits 5-LOX.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.

Europe PMC · ten most recent, newest first