1 reactions
Enzymes & cofactors
Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.
EC 2.3.1.50 SPTLC1/2 1 reactions
Rate-limiting for sphingolipid synthesis; SPTLC1 mutations cause HSAN type I
EC 2.3.1.87 / 2.1.1.4 AANAT / ASMT 1 reactions
Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus
EC 1.1.1.14 SORD 1 reactions
Low in lens/retina/nerve, so sorbitol is trapped in diabetes
EC 2.7.8.27 SGMS1 / SGMS2 1 reactions
EC 1.14.14.17 SQLE 1 reactions
1 reactions
EC 1.3.5.1 SDHA-D 1 reactions
SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate
EC 6.2.1.4 / 6.2.1.5 SUCLG1 / SUCLA2 / SUCLG2 1 reactions
EC 2.8.3.5 OXCT1 1 reactions
SCOT deficiency: ketoacidosis; absent in liver, which is why liver cannot use ketones
EC 2.8.2.- SULT1A1 / SULT2A1 1 reactions
1 reactions
EC 3.1.2.14 FASN 1 reactions
1 reactions
EC 2.4.2.4 TYMP 1 reactions
1 reactions
1 reactions
EC 2.2.1.2 TALDO1 1 reactions
1 reactions
EC 1.14.16.4 TPH1 / TPH2 1 reactions