What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
SAM + methyl acceptor → S-adenosylhomocysteine (SAH) + methylated acceptor
Converts S-adenosylmethionine (SAM) into S-adenosylhomocysteine (SAH)
› Notes
A large family of SAM-dependent methyltransferases transfers the activated methyl group to substrates such as DNA, RNA, norepinephrine, phosphatidylethanolamine, guanidinoacetate, and catechols. No additional ATP is used in the transfer, but SAM cleavage makes methyl transfer strongly favorable; this is the defining transmethylation step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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