Junction / hub Pathway metabolite unreviewed

S-adenosylmethionine (SAM)

Pathways

Reactions involving S-adenosylmethionine (SAM)

Every recorded step where this molecule takes part

All 6 Consumed 4 Produced 2

consumed Phosphatidylethanolamine N-methyltransferase (PEMT) Phospholipid Synthesis (Kennedy / CDP pat… ST-0310

Phosphatidylethanolamine + 3 SAM -> phosphatidylcholine + 3 SAH
consumed Phenylethanolamine N-methyltransferase (PNMT) Catecholamine Synthesis ST-0344

Norepinephrine + SAM -> epinephrine + SAH
consumed SAM-dependent methyltransferases Methionine Cycle / Transmethylation (SAM … ST-0171

SAM + methyl acceptor → S-adenosylhomocysteine (SAH) + methylated acceptor
consumed COMT / TPMT / methyltransferases Phase II - Conjugation ST-0374

Substrate + SAM -> methylated metabolite + SAH
produced Methionine adenosyltransferase (MAT) Methionine Cycle / Transmethylation (SAM … ST-0170

L-methionine + ATP → S-adenosylmethionine (SAM) + Pᵢ + PPᵢ
produced Serotonin N-acetyltransferase (AANAT) + ASMT/HIOMT Serotonin & Melatonin Synthesis ST-0348

Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin

Showing all 6 reactions.

Produced in one pathway, consumed in another

7 links

Produced in		Consumed in	Link
Methionine Cycle / Transmethylation (SAM Cy…	→	Catecholamine Synthesis	within category
Methionine Cycle / Transmethylation (SAM Cy…	→	Phase II - Conjugation	cross-category
Methionine Cycle / Transmethylation (SAM Cy…	→	Phospholipid Synthesis (Kennedy / CDP pathw…	cross-category
Serotonin & Melatonin Synthesis	→	Catecholamine Synthesis	within category
Serotonin & Melatonin Synthesis	→	Methionine Cycle / Transmethylation (SAM Cy…	within category
Serotonin & Melatonin Synthesis	→	Phase II - Conjugation	cross-category
Serotonin & Melatonin Synthesis	→	Phospholipid Synthesis (Kennedy / CDP pathw…	cross-category

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