unreviewed

Methionine adenosyltransferase (MAT)

1 reactions · 1 pathways

Cofactors used

ATP Pi PPi SAM

What it does, reaction by reaction

1 reactions

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol

step 1 Irreversible

L-methionine + ATP → S-adenosylmethionine (SAM) + Pᵢ + PPᵢ

Converts Methionine ATP into S-adenosylmethionine (SAM) Pi PPi

› Notes

Methionine adenosyltransferase (MAT; MAT I/III in adult liver, MAT II extrahepatically) transfers the adenosyl moiety of ATP to methionine. ATP is cleaved to tripolyphosphate equivalents (Pᵢ + PPᵢ, with PPᵢ hydrolysis driving the reaction); this is an essentially irreversible activation step that consumes three high-energy phosphate bonds.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Methionine Cycle / Transmethylation (SAM Cycle, homocysteine)

Accelerated by

Methionine availability; demand for SAM

Inhibited by

Product/SAM accumulation; oxidative or liver injury can impair isoenzyme activity

Hormonal control

Insulin, glucagon, and nutritional state alter hepatic MAT expression indirectly

Recent literature

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