unreviewed
COMT / TPMT / methyltransferases
1 reactions · 1 pathways
Cofactors used
Clinical / pharmacological. TPMT deficiency: azathioprine/6-MP myelosuppression
What it does, reaction by reaction
1 reactions
Phase II - Conjugation Xenobiotic & Drug Metabolism · Cytosol + ER
step 5
Irreversible/directional
Substrate + SAM -> methylated metabolite + SAH
Converts S-adenosylmethionine (SAM) into S-adenosylhomocysteine
› Notes
TPMT deficiency causes severe myelosuppression with azathioprine and 6-mercaptopurine.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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