Serotonin N-acetyltransferase (AANAT) + ASMT/HIOMT
Cofactors used
Clinical / pharmacological. Slow acetylators: isoniazid neuropathy, hydralazine/procainamide lupus
What it does, reaction by reaction
Serotonin & Melatonin Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
Serotonin + acetyl-CoA -> N-acetylserotonin; then + SAM -> melatonin
Converts Serotonin Acetyl-CoA into N-Acetylserotonin Then S-adenosylmethionine (SAM)
› Notes
Pineal, night-time. AANAT is the rate-controlling, light-suppressed step.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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