unreviewed

Succinate dehydrogenase (Complex II)

1 reactions · 1 pathways

Cofactors used

FAD · B2 (Riboflavin) FADH2 Fe-S cluster · Iron Heme/cytochrome · Iron Ubiquinone (CoQ)

Clinical / pharmacological. SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 6 Reversible

Succinate + FAD ⇌ fumarate + FADH2 (enzyme-bound); ubiquinone is reduced to ubiquinol in the respiratory chain

Converts Succinate FAD into Fumarate FADH2 (enzyme-bound)

› Notes

Required cofactors: covalently bound FAD, iron-sulfur centers, and heme b; electrons pass from FADH2 through Fe–S centers to ubiquinone (CoQ). This reversible step does not pump protons and yields reducing equivalents at the CoQ pool rather than free NADH.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

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