unreviewed

Tissue-specific synthases (PGE synthase; prostacyclin synthase; thromboxane synthase)

1 reactions · 1 pathways

What it does, reaction by reaction

1 reactions

Eicosanoid Synthesis Lipid Metabolism · Cytosol / ER / nuclear membrane

step 3 Irreversible/directional

PGH2 -> PGE2 / PGD2 / PGF2alpha / PGI2 / TXA2

Converts PGH2 into PGE2 / PGD2 / PGF2alpha / PGI2 / TXA2

› Notes

Endothelium favours PGI2 (vasodilator, antiaggregatory); platelets favour TXA2 (vasoconstrictor, proaggregatory) - the basis of low-dose aspirin cardioprotection.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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