rate-limiting unreviewed
Serine palmitoyltransferase (SPT)
1 reactions · 1 pathways
Cofactors used
Clinical / pharmacological. Rate-limiting for sphingolipid synthesis; SPTLC1 mutations cause HSAN type I
What it does, reaction by reaction
1 reactions
Sphingolipid Synthesis Lipid Metabolism · ER + Golgi
step 1
Irreversible rate-limiting
Serine + palmitoyl-CoA -> 3-ketosphinganine + CO2 + CoA-SH
Converts Serine Palmitoyl-CoA into 3-Ketosphinganine CO2 CoA-SH
› Notes
Rate-limiting and committed step; located on the ER.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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