Sorbitol dehydrogenase (SORD)
Cofactors used
Clinical / pharmacological. Low in lens/retina/nerve, so sorbitol is trapped in diabetes
What it does, reaction by reaction
Sorbitol / Polyol Pathway Carbohydrate Metabolism · Cytosol
Sorbitol + NAD+ -> fructose + NADH + H+
Converts Sorbitol NAD+ into Fructose NADH H+
› Notes
Absent or low in lens, retina, kidney and Schwann cells, so sorbitol is trapped there; osmotic damage underlies diabetic cataract, retinopathy and neuropathy. Seminal vesicles use this route to make fructose for sperm.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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