Succinyl-CoA synthetase (succinate thiokinase)
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Succinyl-CoA + GDP + Pi ⇌ succinate + GTP + CoA-SH
Converts Succinyl-CoA GDP Pi into Succinate GTP CoA-SH
› Notes
Required substrates/cofactors: GDP (or ADP in some tissue-specific isoenzymes), inorganic phosphate, and Mg2+. This reversible step produces the cycle’s direct high-energy phosphate: 1 GTP, readily converted to ATP by nucleoside diphosphate kinase.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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