EC 4.2.1.11 ENO1 / ENO2 / ENO3 3 reactions
Enzymes & cofactors
Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.
Showing enzymes whose reactions use Mg2+.
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EC 2.7.2.3 PGK1 3 reactions
EC 1.2.4.1 PDHA1 3 reactions
PDC deficiency (X-linked): lactic acidosis, neurological disease; thiamine-responsive forms
EC 2.7.1.1 / 2.7.1.2 HK1-3 / GCK 2 reactions
GCK mutations: MODY2; HK1 deficiency: haemolytic anaemia
EC 2.7.1.1 / 2.7.1.2 HK1-3 / GCK 2 reactions
GCK mutations: MODY2; HK1 deficiency: haemolytic anaemia
EC 2.7.1.11 PFKM/PFKL 2 reactions
Tarui disease (GSD VII): exercise intolerance, haemolysis
EC 2.7.1.40 PKLR 2 reactions
PK deficiency: chronic non-spherocytic haemolytic anaemia
EC 2.2.1.1 TKT 2 reactions
TPP-dependent; erythrocyte transketolase activity assesses thiamine status
EC 2.7.7.9 UGP2 2 reactions
EC 1.1.1.44 PGD 1 reactions
EC 1.2.4.2 OGDH 1 reactions
Requires the same five cofactors as PDC; thiamine-sensitive
EC 2.7.1.32 CHKA 1 reactions
EC 7.1.2.2 ATP5 genes 1 reactions
Inhibited by oligomycin; bypassed by uncouplers (DNP, UCP1)
EC 2.7.1.6 GALK1 1 reactions
Galactokinase deficiency: isolated cataracts
EC 6.3.2.2 GCLC 1 reactions
Rate-limiting for glutathione synthesis; feedback-inhibited by GSH
EC 2.4.1.186 GYG1 1 reactions
EC 2.7.1.3 KHK 1 reactions
GCK mutations: MODY2; HK1 deficiency: haemolytic anaemia
EC 1.1.1.41 IDH3 1 reactions
Rate-limiting TCA step; IDH1/2 neomorphic mutations produce 2-hydroxyglutarate in glioma/AML
EC 6.4.1.1 PC 1 reactions
PC deficiency: lactic acidosis, hypoglycaemia, neurological disease
EC 4.1.1.32 PCK1 / PCK2 1 reactions