unreviewed

Hepatic fructokinase (ketohexokinase)

1 reactions · 1 pathways

Cofactors used

ATP Mg2+ · Magnesium

Clinical / pharmacological. GCK mutations: MODY2; HK1 deficiency: haemolytic anaemia

What it does, reaction by reaction

1 reactions

Fructose Metabolism (Fructolysis) Carbohydrate Metabolism · Cytosol

step 1 Irreversible

Fructose + ATP → fructose-1-phosphate + ADP

Converts Fructose ATP into Fructose-1-phosphate ADP

› Notes

Hepatic fructokinase (ketohexokinase) uses ATP and Mg2+ to phosphorylate fructose at carbon 1. This reaction is effectively irreversible and has high capacity but is not tightly feedback-regulated; rapid flux can transiently consume ATP and phosphate when fructose intake is very high.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

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