What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
3-Phosphoglycerate + ATP → 1,3-bisphosphoglycerate + ADP
Converts 3-Phosphoglycerate ATP into 1,3-Bisphosphoglycerate ADP
› Notes
Phosphoglycerate kinase requires ATP and Mg2+. This is the reverse of glycolytic substrate-level phosphorylation and occurs twice for each glucose produced.
Glycolysis Carbohydrate Metabolism · Cytosol
1,3-Bisphosphoglycerate + ADP → 3-phosphoglycerate + ATP
Converts 1,3-Bisphosphoglycerate ADP into 3-Phosphoglycerate ATP
› Notes
Phosphoglycerate kinase requires Mg2+ and catalyzes reversible substrate-level phosphorylation. Occurring twice per glucose, this first payoff reaction produces two ATP and thereby repays the two ATP invested in steps 1 and 3.
Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration · Cytosol
1,3-Bisphosphoglycerate + ADP ⇌ 3-phosphoglycerate + ATP
Converts 1,3-Bisphosphoglycerate ADP into 3-Phosphoglycerate ATP
› Notes
Required cofactors: ADP and Mg2+. This reversible substrate-level phosphorylation step produces the first ATP-generating reaction of glycolysis; because it occurs twice per glucose, it replaces the two ATP invested earlier.
Showing all 3 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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