rate-limiting unreviewed

Isocitrate dehydrogenase (mitochondrial NAD+-dependent IDH3)

1 reactions · 1 pathways

Cofactors used

Mg2+ · Magnesium Mn2+ NAD+ · B3 (Niacin) NADH · B3 (Niacin)

Clinical / pharmacological. Rate-limiting TCA step; IDH1/2 neomorphic mutations produce 2-hydroxyglutarate in glioma/AML

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 3 Irreversible rate-limiting

Isocitrate + NAD+ → oxalosuccinate + NADH + H+; oxalosuccinate → alpha-ketoglutarate + CO2

Converts Isocitrate NAD+ into Oxalosuccinate NADH H+

› Notes

Required cofactors: NAD+ and Mg2+ or Mn2+. This is an essentially irreversible, rate-limiting regulatory step of the cycle; the CO2 released in the first turn is not necessarily derived from the newly introduced acetyl carbons.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Citric Acid Cycle (TCA / Krebs Cycle)

Listed there as: Isocitrate dehydrogenase (IDH3)

Accelerated by

ADP, Ca2+ in muscle

Inhibited by

ATP, NADH

Hormonal control

Ca2+ released during contraction activates IDH3; hormonal effects are largely indirect through energy demand and substrate supply

Recent literature

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