unreviewed

Alpha-ketoglutarate dehydrogenase complex

1 reactions · 1 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid) FAD · B2 (Riboflavin) Lipoamide Mg2+ · Magnesium NAD+ · B3 (Niacin) NADH · B3 (Niacin) TPP (B1) · B1 (Thiamine)

Clinical / pharmacological. Requires the same five cofactors as PDC; thiamine-sensitive

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 4 Irreversible

Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+

Converts Alpha-ketoglutarate CoA-SH NAD+ into Succinyl-CoA CO2 NADH H+

› Notes

Required cofactors: TPP, lipoic acid/lipoamide, CoA-SH, FAD, NAD+, and Mg2+, with E1, E2, and E3 activities analogous to PDC. This is an essentially irreversible and important regulatory step; it is inhibited by NADH and succinyl-CoA.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Citric Acid Cycle (TCA / Krebs Cycle)

Accelerated by

Ca2+ in skeletal and cardiac muscle; ADP

Inhibited by

NADH, succinyl-CoA, high ATP

Hormonal control

Ca2+-linked adrenergic/muscle contraction signals promote activity; endocrine control is mostly indirect

Recent literature

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