Junction / hub Pathway metabolite unreviewed

Succinyl-CoA

Pathways

Reactions involving Succinyl-CoA

Every recorded step where this molecule takes part

All 7 Consumed 3 Produced 4

consumed Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1) Ketolysis (Ketone Body Utilization) ST-0088

Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
consumed Mitochondrial ALA synthase (ALAS) Heme Biosynthesis (Porphyrin Pathway) ST-0177 rate-limiting

Glycine + succinyl-CoA → δ-aminolevulinate (ALA) + CO₂ + CoA
consumed Succinyl-CoA synthetase (succinate thiokinase) Citric Acid Cycle (TCA / Krebs Cycle) ST-0273

Succinyl-CoA + GDP + Pi ⇌ succinate + GTP + CoA-SH
produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147

Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
produced Methylmalonyl-CoA mutase (MMUT) Propionyl-CoA to Succinyl-CoA (anaplerosi… ST-0378

L-Methylmalonyl-CoA -> succinyl-CoA
produced Propionyl-CoA carboxylase Pyrimidine Degradation ST-0251

Propionyl-CoA → succinyl-CoA
produced Alpha-ketoglutarate dehydrogenase complex Citric Acid Cycle (TCA / Krebs Cycle) ST-0272

Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+

Showing all 7 reactions.

Produced in one pathway, consumed in another

11 links

Produced in		Consumed in	Link
Amino Acid Catabolism Overview (glucogenic …	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Heme Biosynthesis (Porphyrin Pathway)	within category
Amino Acid Catabolism Overview (glucogenic …	→	Ketolysis (Ketone Body Utilization)	cross-category
Citric Acid Cycle (TCA / Krebs Cycle)	→	Heme Biosynthesis (Porphyrin Pathway)	cross-category
Citric Acid Cycle (TCA / Krebs Cycle)	→	Ketolysis (Ketone Body Utilization)	cross-category
Propionyl-CoA to Succinyl-CoA (anaplerosis)	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Propionyl-CoA to Succinyl-CoA (anaplerosis)	→	Heme Biosynthesis (Porphyrin Pathway)	within category
Propionyl-CoA to Succinyl-CoA (anaplerosis)	→	Ketolysis (Ketone Body Utilization)	cross-category
Pyrimidine Degradation	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Pyrimidine Degradation	→	Heme Biosynthesis (Porphyrin Pathway)	cross-category
Pyrimidine Degradation	→	Ketolysis (Ketone Body Utilization)	cross-category

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