Multiple pathway-specific catabolic enzymes
What it does, reaction by reaction
Amino Acid Catabolism Overview (glucogenic vs. ketogenic amino acids; brief overview of branched-chain amino acid catabolism and phenylalanine/tyrosine catabolism as representative examples) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
Converts Amino acid carbon skeleton (glucogenic) into Pyruvate Oxaloacetate Alpha-ketoglutarate Succinyl-CoA Fumarate
› Notes
Multiple pathway-specific enzymes produce pyruvate (alanine, serine, glycine, cysteine, threonine, tryptophan), oxaloacetate (aspartate, asparagine), α-ketoglutarate (glutamate, glutamine, proline, arginine, histidine), succinyl-CoA (valine, isoleucine, methionine, threonine), or fumarate (phenylalanine, tyrosine). Conversion of these intermediates to glucose requires hepatic or renal gluconeogenesis and consumes ATP/GTP and reducing power; entry into the TCA cycle alone is not synonymous with net glucose production.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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