Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1)
Clinical / pharmacological. SCOT deficiency: ketoacidosis; absent in liver, which is why liver cannot use ketones
What it does, reaction by reaction
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
Converts Acetoacetate Succinyl-CoA into Acetoacetyl-CoA Succinate
› Notes
Succinyl-CoA:3-ketoacid CoA transferase (SCOT; 3-oxoacid CoA-transferase, OXCT1) activates acetoacetate by transferring CoA from succinyl-CoA. This is the committed, functionally rate-determining step of ketone-body utilization; it bypasses succinyl-CoA synthetase and therefore sacrifices the GTP that would otherwise be generated in the TCA cycle. Liver lacks SCOT, preventing futile cycling.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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