unreviewed

Phosphoenolpyruvate carboxykinase (PEPCK)

1 reactions · 1 pathways

Cofactors used

GTP Mg2+ · Magnesium Mn2+

What it does, reaction by reaction

1 reactions

Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER

step 4 Irreversible

Oxaloacetate + GTP → phosphoenolpyruvate + GDP + CO2

Converts Oxaloacetate GTP into Phosphoenolpyruvate GDP CO2

› Notes

Cytosolic or mitochondrial phosphoenolpyruvate carboxykinase (PEPCK) requires GTP and Mg2+/Mn2+. Decarboxylation drives phosphorylation to PEP; together with step 1, it bypasses pyruvate kinase and is effectively irreversible. Mitochondrially formed PEP can be exported when the mitochondrial isoenzyme is used.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Gluconeogenesis

Listed there as: Phosphoenolpyruvate carboxykinase

Accelerated by

Substrate availability

Inhibited by

ADP

Hormonal control

Glucagon and cortisol induce transcription; insulin represses transcription

Recent literature

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