F0F1-ATP synthase (Complex V), F1 sector
Cofactors used
Clinical / pharmacological. Inhibited by oligomycin; bypassed by uncouplers (DNP, UCP1)
What it does, reaction by reaction
Oxidative Phosphorylation (Chemiosmotic Mechanism and ATP Synthase) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
Rotational conformational catalysis: ADP + Pi → ATP at F1 beta subunits
› Notes
Required substrates/cofactors: ADP, inorganic phosphate, Mg2+, and proton-driven rotation. ATP formation at a tight site is not itself the major energy-requiring event; proton-motive force chiefly drives rotational conformational changes that release tightly bound ATP.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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