gamma-Glutamylcysteine synthetase (GCL)
Cofactors used
Clinical / pharmacological. Rate-limiting for glutathione synthesis; feedback-inhibited by GSH
What it does, reaction by reaction
Glutathione Metabolism (gamma-Glutamyl Cycle) Amino Acid & Nitrogen Metabolism · Cytosol
L-Glutamate + L-cysteine + ATP -> gamma-glutamylcysteine + ADP + Pi
Converts Glutamate Cysteine ATP into gamma-Glutamylcysteine ADP Pi
› Notes
Rate-limiting step; feedback-inhibited by GSH. Cysteine availability is usually the limiting substrate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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