unreviewed

UDP-glucose pyrophosphorylase

2 reactions · 2 pathways

Cofactors used

Mg2+ · Magnesium UTP PPi

What it does, reaction by reaction

2 reactions

Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism · Cytosol (glycogen particle)

step 3 Irreversible

Glucose-1-phosphate + UTP → UDP-glucose + PPi

Converts Glucose-1-phosphate UTP into UDP-glucose PPi

› Notes

UDP-glucose pyrophosphorylase requires UTP and Mg2+ to activate glucose as UDP-glucose. Subsequent hydrolysis of pyrophosphate by ubiquitous inorganic pyrophosphatase (PPi + H2O → 2 Pi) drives the overall activation forward; the activation sequence is effectively irreversible.

Uronic Acid Pathway Carbohydrate Metabolism · Cytosol

step 1 Irreversible/directional

Glucose-1-phosphate + UTP -> UDP-glucose + PPi

Converts Glucose-1-phosphate UTP into UDP-glucose PPi

› Notes

Shared entry with glycogenesis.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

Load 10 most recent

Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.

Europe PMC · ten most recent, newest first