EC 1.8.1.4 DLD 4 reactions
Enzymes & cofactors
Search by name, gene symbol, EC number or the disorder it causes. Open any enzyme to see every reaction it catalyses, what accelerates it and what inhibits it.
Showing enzymes whose reactions use NAD+.
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EC 1.2.1.12 GAPDH 3 reactions
EC 1.1.1.8 GPD1 2 reactions
EC 1.1.1.37 MDH1 2 reactions
EC 1.1.1.30 BDH1 2 reactions
EC 1.3.8.- ACADM/ACADVL 1 reactions
MCAD deficiency: hypoketotic hypoglycaemia, dicarboxylic aciduria, SIDS-like presentation
EC 1.2.4.2 OGDH 1 reactions
Requires the same five cofactors as PDC; thiamine-sensitive
EC 2.6.1.40 AGXT2 1 reactions
EC 1.2.4.4 BCKDHA/B, DBT 1 reactions
Maple syrup urine disease: burnt-sugar urine, ketoacidosis; thiamine-responsive variants
EC 7.1.1.2 NDUFA-S subunits 1 reactions
1 reactions
EC 1.4.1.3 GLUD1 1 reactions
Activating mutations: hyperinsulinism-hyperammonaemia syndrome
EC 1.1.1.27 LDHA/LDHB 1 reactions
Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
1 reactions
EC 1.1.1.205 IMPDH1 / IMPDH2 1 reactions
EC 1.1.1.41 IDH3 1 reactions
Rate-limiting TCA step; IDH1/2 neomorphic mutations produce 2-hydroxyglutarate in glioma/AML
EC 1.1.1.35 HADH / HADHA 1 reactions
MCAD deficiency: hypoketotic hypoglycaemia, dicarboxylic aciduria, SIDS-like presentation
EC 1.1.1.27 LDHA/LDHB 1 reactions
Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
EC 1.1.1.27 LDHA/LDHB 1 reactions
Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
EC 1.1.1.37 MDH2 1 reactions