Complex I (NADH:ubiquinone oxidoreductase)
What it does, reaction by reaction
Electron Transport Chain (Complexes I–IV) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
NADH + H+ + ubiquinone (Q) → NAD+ + ubiquinol (QH2)
Converts NADH H+ Ubiquinone (CoQ) into NAD+ Ubiquinol (CoQH2)
› Notes
Required cofactors: FMN, Fe–S clusters, NADH, and ubiquinone. For each NADH oxidized and Q reduced, Complex I translocates 4 H+ from matrix to intermembrane space; this electron-entry step is not normally called the committed rate-limiting step of oxidative phosphorylation, but it is a major regulated redox entry point.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Electron Transport Chain (Complexes I–IV)
NADH availability, ADP/ATP demand, adequate O2 downstream
Rotenone, piericidin A, amobarbital; excess NADH can favor reduced-state backpressure
Thyroid hormone can increase mitochondrial respiratory capacity over time; acute control is principally acceptor control by ADP and substrate redox state
Recent literature
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