L-3-hydroxyacyl-CoA dehydrogenase
Cofactors used
Clinical / pharmacological. MCAD deficiency: hypoketotic hypoglycaemia, dicarboxylic aciduria, SIDS-like presentation
What it does, reaction by reaction
Beta-Oxidation of Fatty Acids Lipid Metabolism · Mitochondrial matrix (peroxisome for VLCFA)
L-3-Hydroxyacyl-CoA + NAD+ → 3-ketoacyl-CoA + NADH + H+
Converts L-3-Hydroxyacyl-CoA NAD+ into 3-Ketoacyl-CoA NADH H+
› Notes
L-3-hydroxyacyl-CoA dehydrogenase oxidizes the β-hydroxyl group using NAD+. NADH donates electrons to complex I of the respiratory chain.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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