Cytosolic glycerol-3-phosphate dehydrogenase (GPD1)
Cofactors used
What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Dihydroxyacetone phosphate + NADH + H+ ⇌ glycerol-3-phosphate + NAD+
Converts Dihydroxyacetone phosphate NADH H+ into Glycerol-3-phosphate NAD+
› Notes
Cytosolic glycerol-3-phosphate dehydrogenase supplies glycerol-3-phosphate from glycolytic DHAP, the predominant adipocyte source. This reaction couples TAG synthesis to glucose uptake and glycolysis.
Glycerol-3-Phosphate Shuttle Energy Metabolism & Cellular Respiration · Cytosol + inner mitochondrial membrane
Dihydroxyacetone phosphate + NADH + H+ -> glycerol-3-phosphate + NAD+
Converts Dihydroxyacetone phosphate NADH H+ into Glycerol-3-phosphate NAD+
› Notes
Cytosolic half of the shuttle.
Showing all 2 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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