Lactate dehydrogenase (LDHB) + gluconeogenic enzymes
Cofactors used
Clinical / pharmacological. Regenerates NAD+ anaerobically; LDHA deficiency causes exercise-induced myoglobinuria
What it does, reaction by reaction
Cori Cycle (lactate shuttle) Carbohydrate Metabolism · Cytosol (muscle) + liver
Lactate -> pyruvate -> glucose (liver, 6 ATP equivalents)
Converts Lactate into Pyruvate
› Notes
Net cost of 4 ATP equivalents per cycle, shifting the energy burden to liver. Metformin-associated and hypoxic lactic acidosis reflect failure of this arm.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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